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John Turk Selected Research

Calcium-Independent Phospholipases A2

9/2012Disturbed brain phospholipid and docosahexaenoic acid metabolism in calcium-independent phospholipase A(2)-VIA (iPLA(2)β)-knockout mice.
7/2012Smooth muscle-specific expression of calcium-independent phospholipase A2β (iPLA2β) participates in the initiation and early progression of vascular inflammation and neointima formation.
2/2012Group VIA PLA2 (iPLA2β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signaling.
1/2012Lung endothelial cell platelet-activating factor production and inflammatory cell adherence are increased in response to cigarette smoke component exposure.
1/2012Group VIB Phospholipase A(2) promotes proliferation of INS-1 insulinoma cells and attenuates lipid peroxidation and apoptosis induced by inflammatory cytokines and oxidant agents.
4/2011Platelet-activating factor and metastasis: calcium-independent phospholipase A2β deficiency protects against breast cancer metastasis to the lung.
10/2010Effects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexin.
10/2010Group VIA phospholipase A2 in both host and tumor cells is involved in ovarian cancer development.
7/2010Endothelial cell prostaglandin I(2) and platelet-activating factor production are markedly attenuated in the calcium-independent phospholipase A(2)beta knockout mouse.
7/2010Protection of pancreatic beta-cells by group VIA phospholipase A(2)-mediated repair of mitochondrial membrane peroxidation.
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John Turk Research Topics

Disease

16Insulinoma
05/2014 - 04/2002
4Obesity
01/2021 - 06/2010
4Insulin Resistance
01/2021 - 06/2010
4Inflammation (Inflammations)
10/2016 - 01/2012
4Diabetes Mellitus
05/2014 - 02/2004
4Hyperglycemia
03/2013 - 01/2002
3Glucose Intolerance
10/2020 - 07/2006
2Infections
04/2016 - 10/2011
2Dystonia (Limb Dystonia)
09/2012 - 11/2010
2Parkinsonian Disorders (Parkinsonism)
09/2012 - 11/2010
2Neuroaxonal Dystrophies (Neuroaxonal Dystrophy, Late Infantile)
09/2012 - 02/2008
2Lung Diseases (Lung Disease)
01/2012 - 07/2010
2Neoplasms (Cancer)
04/2011 - 10/2010
2Breast Neoplasms (Breast Cancer)
04/2011 - 06/2008
2Atherosclerosis
07/2010 - 11/2007
2Body Weight (Weight, Body)
07/2010 - 06/2010
2Alzheimer Disease (Alzheimer's Disease)
10/2006 - 12/2004
1Myocarditis (Carditis)
04/2016
1Chagas Disease (American Trypanosomiasis)
04/2016
1Muscular Dystrophies (Muscular Dystrophy)
12/2015
1Morbid Obesity
07/2015
1Sleep Deprivation
05/2015
1Parkinson Disease (Parkinson's Disease)
08/2014
1Disease Progression
08/2014
1Non-alcoholic Fatty Liver Disease
06/2013
1Neointima
07/2012
1Cardiovascular Diseases (Cardiovascular Disease)
07/2012
1Hypertension (High Blood Pressure)
12/2011
1Tuberculosis (Tuberculoses)
10/2011
1Neoplasm Metastasis (Metastasis)
04/2011
1Ascites
10/2010
1Ovarian Neoplasms (Ovarian Cancer)
10/2010
1Ovarian Epithelial Carcinoma
10/2010
1Carcinogenesis
10/2010

Drug/Important Bio-Agent (IBA)

24Calcium-Independent Phospholipases A2IBA
09/2012 - 04/2002
10Insulin (Novolin)FDA Link
01/2021 - 01/2002
10Glucose (Dextrose)FDA LinkGeneric
10/2020 - 12/2003
10Phospholipases (Phospholipase)IBA
04/2016 - 02/2004
7CalciumIBA
04/2016 - 02/2004
6Phospholipases A2 (Phospholipase A2)IBA
10/2016 - 12/2003
5Proteins (Proteins, Gene)FDA Link
06/2013 - 12/2004
56- (bromomethylene)tetrahydro- 3- (1- naphthaleneyl)- 2H- pyran- 2- oneIBA
07/2012 - 02/2004
4Fatty Acids (Saturated Fatty Acids)IBA
06/2013 - 07/2010
3LipidsIBA
01/2021 - 07/2010
3Platelet Activating FactorIBA
04/2016 - 04/2011
3EnzymesIBA
08/2012 - 12/2004
3Protein Isoforms (Isoforms)IBA
05/2010 - 12/2003
3Phospholipids (Phosphatides)FDA LinkGeneric
05/2006 - 10/2004
2LysophospholipidsIBA
01/2021 - 10/2016
2Arachidonic Acid (Vitamin F)IBA
10/2016 - 02/2012
2CytokinesIBA
07/2012 - 01/2012
2Streptozocin (Streptozotocin)FDA Link
01/2012 - 07/2006
2IronIBA
11/2010 - 02/2008
2Dietary Fats (Dietary Fat)IBA
06/2010 - 05/2005
2Amyloid (Amyloid Fibrils)IBA
10/2006 - 12/2004
1Phosphatidylcholines (Phosphatidylcholine)IBA
01/2021
1Lysophosphatidylcholines (Lysophosphatidylcholine)IBA
01/2021
1EicosanoidsIBA
10/2016
1Adenosine Triphosphatases (ATPase)IBA
12/2015
1sarcolipinIBA
07/2015
1CLOCK ProteinsIBA
05/2015
1Biomarkers (Surrogate Marker)IBA
08/2014
1Dopamine (Intropin)FDA LinkGeneric
08/2014
1AntioxidantsIBA
08/2014
1PalmitatesIBA
05/2014
1Reactive Oxygen Species (Oxygen Radicals)IBA
05/2014
1Nonesterified Fatty Acids (NEFA)IBA
05/2014
1CeramidesIBA
05/2014
1Activating Transcription Factor 4IBA
05/2014
1Transcription Factor CHOPIBA
05/2014
1Caspase 3 (Caspase-3)IBA
05/2014
1NADP (NADPH)IBA
04/2014
1Oxidoreductases (Dehydrogenase)IBA
04/2014
1DiglyceridesIBA
06/2013
1Liver GlycogenIBA
06/2013
1Phosphotransferases (Kinase)IBA
06/2013
1Protein Kinase CIBA
06/2013
1JNK Mitogen-Activated Protein KinasesIBA
06/2013
1Fatty Acid-Binding ProteinsIBA
06/2013
1Protein Phosphatase 2 (Protein Phosphatase 2A)IBA
06/2013
1Mitochondrial Trifunctional ProteinIBA
06/2013
1SugarsIBA
03/2013
1Antisense OligonucleotidesIBA
07/2012
1p38 Mitogen-Activated Protein KinasesIBA
02/2012
1tert-ButylhydroperoxideIBA
01/2012
1SmokeIBA
01/2012
1Oxidants (Oxidizing Agents)IBA
01/2012
1GTP-Binding Proteins (G-Protein)IBA
12/2011
1GlycolipidsIBA
10/2011
1LipopolysaccharidesIBA
10/2011
1Calcium-Calmodulin-Dependent Protein KinasesIBA
10/2010
1lysophosphatidic acidIBA
10/2010
1Small Interfering RNA (siRNA)IBA
10/2010
1Antineoplastic Agents (Antineoplastics)IBA
10/2010
1Fatty Acid Synthases (Fatty Acid Synthase)IBA
07/2010
1Apolipoproteins E (ApoE)IBA
07/2010
1platelet activating factor receptorIBA
07/2010
1CarbohydratesIBA
06/2010

Therapy/Procedure

1Therapeutics
08/2014
1Ligation
07/2012